LA County Confirms Three Clade I Mpox Cases Without Travel History, Sparking Local Transmission Investigation

Los Angeles County health officials are investigating possible local spread of a more severe strain of mpox after confirming three cases in patients with no recent travel to regions where the virus typically circulates, raising concerns for Inglewood, Compton, and surrounding communities.

The Los Angeles County Department of Public Health announced two cases of clade I mpox since Thursday, with the City of Long Beach’s health agency reporting a third confirmed clade I infection earlier this week. All three individuals were hospitalized but are now recovering at home, according to county health officials.

“The confirmation of a third case with no travel history raises concerns about possible local spread in Los Angeles County,” said Dr. Muntu Davis, Los Angeles County health officer, in a press release.

These cases are believed to be among the first clade I mpox infections in the nation involving people with no known history of travel to endemic areas. County officials report no known links between the three patients at this time.

What Makes Clade I More Concerning

Compared to clade II mpox, which caused the 2022 global outbreak and sporadic clusters in the United States, clade I mpox is more likely to cause severe illness and death, according to health officials. The strain has prompted enhanced surveillance and contact tracing across Los Angeles County.

So far in 2025, Los Angeles County has confirmed 118 cases of the less severe clade II mpox strain.

Symptoms and Prevention

Mpox symptoms include rash, fever, or swollen lymph nodes. Health officials emphasize that mpox continues to spread primarily through close, intimate contact with symptomatic people, mainly during sexual activity.

Residents experiencing symptoms should seek medical attention immediately and request testing.

Free Vaccination Available Across LA County

The JYNNEOS vaccine provides protection against both clade I and clade II mpox. Health officials stress that getting both doses provides the best protection, and second doses can be administered regardless of how long it has been since the first dose.

Inglewood and Compton residents can access the vaccine at:

• Major pharmacy chains including CVS and Walgreens (for insured individuals)

• Public Health Sexual Health Clinics (free for uninsured and underinsured residents)

To locate nearby vaccine locations, visit the Bavarian Nordic Vaccine Locator webpage or call the Public Health Infoline at 1-833-540-0473, seven days a week from 8 a.m. to 8 p.m.

Coordinated Investigation Underway

Public Health is collaborating closely with the California Department of Public Health and the U.S. Centers for Disease Control and Prevention to investigate these cases and identify any additional infections or potential sources.

“Early detection, testing and vaccination are vital to controlling the spread of this virus,” county health officials stated.

For more information about mpox and prevention resources, visit the LA County Department of Public Health website at publichealth.lacounty.gov.